If Oprah hates the handicapped, Apple does not have a heart for left-handed people. You know, people like Barack Obama, Paul McCartney, Fidel Castro, and even Oprah Winfrey herself.
There have been reports, and videos to prove, that the iPhone 4 loses its wireless signal when held on the left hand because the palm blocks the bottom left corner of the phone, where the antenna is located. This causes phone calls to fail.